It's what the huge same series started with: the first installment of Maff Effect was developed by BioWare and published by Microsoft Game Studios and Electronic Arts way back in 2007. Having no Mass Effect controller support and single-player mode only, this game was (and still is) very popular and atmospheric. If you'd like to get to know the ME franchise you'd better start with this game. Still, since Mass Effect controller support was not initially implemented, reWASD can help you enable it.
You can create your own Mass Effect controller layout to play the game on PC with the gamepad. Map keyboard keys to controller buttons, adjust stick deadzones, tune gamepad behavior, and more with the best gamepad mapper: use every feature to make you Mass Effect controller support setting as personalized as you need.
If you prefer using some ready-to-go presets for Mass Effect controller support, you can find them below. Remember, that you can change those settings a bit, to make the perfect Mass Effect controller layout!